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Disorders of the pupil
HELMUT WILHELM Centre for Ophthalmology, University Eye Ho,lpital, University of TUbingen. TUbingen, Germany |
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Plasma Cell Orificial Mucositis
Report of a Case and Review of the Literature John W. White, Jr, MD; Kerry D. Olsen, MD; Peter M. Banks, MD |
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Obesity Treatment for
Socioeconomically Disadvantaged Patients in Primary Care Practice G. Bennelt, PhD; Erica T. Wamer, SeD, MPH; Russell E. Glasgow, PhD; Sandy AS/lew, MPH; Julie GoldmaH, MSW, MPH; Debra P. Rirzwoller, PhD; Karen M. Emmons, PhD; Bemara A. Rosner, PhD; Graham A. Colditz, MD, Dr PH;jorlhe Be Fit, Be Well Study Investigators |
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Red Meat Consumption and Mortality
Results From 2 Prospective Cohort Studies An Pan, PhD; Qi Sun, MD, SeD; Adam M. Belllstein, MD, SeD; Matthias B. Schulze, DrPH; JoAnn E. Manson, MD, DrPH; Meir. StampJer, MD, DrPH; Walter C. Willett, MD, DrPH; Fran!. B. Hu, MD, PhD |
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The Third Wave-Medical Tourism in
the 21st Century Bennett Pafford, MPH, MD |
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Abstract: The high number of uninsured or underinsured Americans and the spiraling cost of healthcare in the United States has spurred growth in patients traveling abroad for affordable healthcare, which has become known as medical tourism. It is projected to become a 521 billion a year industry by 2011. Overseas prices for most procedures, including airfare, are often half the cost of those performed in the United States; some procedures are 80% less. International facilities in India, Thailand, and elsewhere are obtaining Joint Commission International (leI) accreditation and aggressively marketing to Western cllstomers and insurance agencies and advertising high quality standards and personalized service, The acceptance of medial tourism is growing, with a recent poll showing more than 40% ofUS healthcare consumers willing to travel abroad for care, Insurance companies have begun to integrate foreign care into their coverage, offering discounts to patients agreeing to overR seas travel. Physician groups have been slow to respond, even though estimates are that medical tourism may represent $162 billion in lost spending in America by 2012, Some experts think the continued US healthcare cost crisis will drive an increase in medical tourism and international competition, significantly impacting domestic physicians and hospitals, Key 'Vords: AMA policy paper, economic impact, international hospitals, medical offshoring, medical tourism |
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THE DETERMINANTS OF
HEALTH-CARE EXPENDITURE: NEW RESULTS FROM SEMIPARAMETRIC ESTIMATION
HELMUT HERWARTZ' and BERND THEILENb |
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The Brazilian
health system: history, advances, and challenges Jairnilson Paim, Claudia Travassos, Celia Almeida, Ligia Bahia, James Macinko |
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The Bill &
Melinda Gates Foundation’s grant-making programme for global health
David McCoy, Gayatri Kembhavi, Jinesh Patel, Akish Luintel |
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Socioeconomic determinants of infant mortality: a worldwide study of 152
low-, middle-, and high-income countries Schell CO, Reilly M, Rosling H, Peterson S, Ekstrom AM |
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Abstract Background: To reach the Millennium Development Goals for health, influential international bodies advocate for more resources to be directed to the health sector, in particular medical treatment. Yet, health has many determinants beyond the health sector that are less evident than proximate predictors. Aim: To assess the relative importance of major socioeconomic detenninants of population health, measured as infant mortality rate (IMR), at country level. Methods: National-level data from 152 countries based on \Vorld Development Indicators 2003 were used for multivariate linear regression analyses of five socioeconomic predictors of IMR: public spending on health, GNIIcapita, poverty rate, income equality (Gini index), and young female illiteracy rate. Analyses were performed on a global level and stratified for low-, middle-, and high-income countries. Results: In order of importance, GNl/capita, young female illiteracy, and income equality predicted 92% of the variation in national IMR whereas public spending on health and poverty rate were non-significant detenninants when adjusted for confounding. In low-income countries, female illiteracy was more important than GNIIcapita. Income equality (Gini index) was an independent predictor ofIMR in middle-income countries only. In high-income countries none of these predictors was significant. COl/elusions: The relative importance of major health detenninants varies between income levels, thus extrapolating health policies from high- to low-income countries is problematic. Since the size, per se, ofpublic health spending does not independently predict health outcomes, functioning health systems are necessary to make health investments efficient. Potential health gains from improved female education and economic growth should be considered in low- and middle-income countries Key Words: Child mortalitYJfemale literacYJ Gini indexJ GNIJ infant mortality rateJ health determinantJ health expendirut'eJ health systemJ povertYJ socioeconomic |
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Predictors of Avoidable Hospitalizations Among Assisted Living Residents
Marion Becker, RN, PhD, Timothy Boaz, PhD, Ross Andel, PhD, and Anne DeMuth, MPH |
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Food Expenditures and Food
Purchasing Among Low-Income, Urban, African-American Youth Lauren A. Dennisuk, MHS, Anastasia J. Coutinho, MHS, Sonali Suratkar, MHS, Pamela J. Surkan, ScD, Karina Christiansen, BA, Michelle Riley, MHS, RD, Jean A. Anliker RD, PhD, Sangita Sharma, PhD, Joel Gittelsohn, PhD |
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Financing of HIV/AIDS
programme scale-up in low-income and middle-income countries, 2009–31
Robert Hecht, John Stover, Lori Bollinger, Farzana Muhib, Kelsey Case, David de Ferranti |
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Do
we have primary health care reform? The story of the Republic of Serbia
Snezana Simica, Milena Santric Milicevica, Bojana Matejica, Jelena Marinkovicb, Orvill Adamsc |
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Abstract: In 1975, 50 year-old Americans could expect to live slightly longer than most of their Western European counterparts. By 2005, American life expectancy had fallen behind that of most Western European countries. We find that this growing longevity gap is primarily due to real declines in the health of nearelderly Americans, relative to their Western European peers. We use a microsimulation approach to project what US longevity would look like, if US health trends approximated those in Western Europe. The model implies that differences in health can explain most of the growing gap in remaining life expectancy. In addition, we quantify the public finance consequences of this deterioration in health. The model predicts that gradually moving American cohorts to the health status enjoyed by Western Europeans could save up to $1.1 trillion in discounted total health expenditures from 2004 to 2050. 2011 Elsevier Ltd. All rights reserved. |
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Differences in
health between Americans and Western Europeans: Effects on longevity and
public finance Pierre-Carl Michaud a,*, Dana Goldman b, Darius Lakdawalla b, Adam Gailey c, Yuhui Zheng d |
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Abstract: Objective: To provide insight of national activities and international assistance inPHCreform and to assess their effects on technical and allocative efficiency as well as financial sustainability of primary health care in the Republic of Serbia. Materials and methods: Analytical framework of the study consisted of gathering and reviewing of relevant political documents, international assistance project documentation, and analysis of routinely collected national statistical data based on the evaluation model of three groups of criteria: allocative, technical efficiency and financial sustainability in the public sector of Serbia from 2000 to 2007. Time trends were analyzed by Poisson regression models using average annual percentage changes – AAPC, and the percent of targeted change achieved by progress quotient – PQ. Results: Allocative efficiency of the PHC during period of 8 years was improved, but technical efficiency was almost unchanged for all service, except for preschool health care. Financial sustainability was also improved measured by indirect indicators of health expenditure. Conclusions: Results of this study indicated that we are on the right track with PHC reform, and international support is in accordance with the reform goals. Our approach has been and will remain incremental, gradualist and multi-faceted. © 2010 Elsevier Ireland Ltd. All rights reserved |
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Critical Care
Rationing: International Comparisons Timothy W. Evans, Stefano Nava, Guillermo Vazquez Mata, Bertrand Guidet, Elisa Estenssoro, Robert Fowler, Leslie P. Scheunemann, Douglas White and Constantine A. Manthous |
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Assessing health system
performance in developing countries: A review of the literature
Margaret Elizabeth Kruka,b, Lynn P. Freedman b |
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An
assessment of interactions between global health initiatives and country
health systems World Health Organization Maximizing Positive Synergies Collaborative Group* |
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ACTA PHARMACEUTICA HUNGARICA ASSESSMENT OF THE PHARMACEUTICAL EXPENDITURE IN H Inotai A;Meresz G;Kalo Z |
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Use of
Psychostimulants in Patients with Dementia Christian R Dolder, Lauren Nicole Davis, and Jonathan McKinsey |
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Turbocharging the brain Gary Stix |
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Premotor signs and symptoms of multiple system atrophy Milica Jecmenica-Lukic, Werner Poewe, Eduardo Tolosa, Gregor K Wenning |
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Pharmakologisches Neuroenhancement
und,"Hirndoping" Chancen und Risiken |
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Methylphenidate for the Treatment of Apathy in Alzheimer Disease
Prediction of Response Using Dextroamphetamine Challenge Nathan Herrmann, MD, FRCP(C), Lana S. Rothenburg, MSc, Sandra E. Black, MD, FRCP(C), Michelle Ryan, MSc,Barbara A. Liu, MD, FRCP(C),Usoa E. Busto, PharmD, and Krista Lanctot, PhD |
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Abstract: Apathy is a common behavioral symptom of Alzheimer's disease (AD), being present in up to 70% ofpatients. Apathy in AD and non-AD populations has been associated with dysfunction in the dopaminergic brain reward system, suggesting that phannacotherapeutic targeting of this system may be an effective treatment for apathy in AD. We therefore performed a randomized, double~blind, placebo-controlled crossover trial ofmethylphenidate in a sample of 13 apathetic AD patients (6 men, 7 women; age mean 77.9 years [SD, 7.8 years]; Mini Mental Status Examination score, 19.9 [SD, 4.7]). Patients were treated with methylphenidate (10 mg PO twice a day) or an identical placebo in two 2-week phases separated by a l~week placebo washout. All patients participated in a dextroamphetamine challenge test (one lO-mg oral dose) before treatment with methylphenidate to gauge the functional integrity of the dopamine brain reward system. Overall, patients demonstrated greater improvement with methylphenidate compared with placebo according to Apathy Evaluation Scale total change scores (end of treatment - baseline: Wilcoxon Z = -2.00; P = 0.047). However, a significantly greater proportion of patients experienced at least 1 adverse event with methylphenidate compared with placebo (3 vs Ij X2 = 4.33, P = 0.038). Two patients experienced serious adverse events with methylphenidate, consisting ofdelusions, agitation, anger, irritability, and insomnia, which resolved upon discontinuation of the medication. Response to methylphenidate was associated with increases in inattention on a continuous perfonnance task after dextroamphetamine challenge. Psychostimulants may be effective in treating features of apathy in AD, and dopaminergic changes may predict response. |
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Methylphenidate for Apathy and Functional Status in Dementia of the
Alzheimer Type Prasad R Padala, M.D., WilliamJ. Burke, M.D., Valerie K. Shostrolll, M.S., Subhash C. Bhatia, M.D., Steven P. Wenge M.D., Jane F. Pottel M.D., Fl'ederick Petty, Ph.D., M.D. |
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Objective: Apathy is the most commoll behavioral problem ill persolls with demelltia of the Alzheimer type (DA1). Treatmellt of apathy ill DAT is Ilot systematically studied. The pwpose of this stuely was to evaluate the response of apathy to methylphenidate treatment and to e.\·arnine whetherfimctiotltll status improved. Methods: The authors conducted a 12week opell-Iabeled study with immediate release formulation of methylphenidate. Twenty-three patiellts with DAT sco";ng >40 on the Apathy Evaluation Scale (AES) were recruited. Repeated measures allalysis of variance and correlatlon analysis were performed. Results: None of the patients dropped out of the study because of adverse events. Significant improvement in apathy was noted du";ng 12 weeks. SignIficant hnprovement was also noted in depression, lYlini-A1ental State Ryaminatioll score, andJunctional status. I1Jere was no correlation bettveen changes in the AES and depression scores. Conclusions: Metljylphenidate was well tolerated in these patients with DAT. Apathy improved with the use of methylphenidate. (Am J Geriatr Psychiatry 2010; 18: 371-374) |
| Skeletal muscle involvement in human immunodeficiency virus infection a report of four cases. |
|
HIV-related
neuromuscular diseases: nemaline myopathy, amyotrophic lateral sclerosis
and bibrachial amyotrophic diplegia L.P. Rowland Neurological Institute, Columbia University Medical Center, New York, NY, USA |
| Annals of Internal Medicine |
|
Medical Clinics Versus Usual Care for Patients With Both Diabetes and
Hypertension David Edelman, MD; Sonja K. Fredrickson, MD; Stephanie D. Melnyk, PharmD; Cynthia J. Coffman, PhD; Amy S. Jeffreys, MStat; Santanu Datta, PhD; George L. Jackson, PhD; Amy C. Harris, BA; Natia S. Hamilton, BS; Helen Stewart, RN; Jeannette Stein, MD; and Morris Weinberger, PhD |
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Obstructive Syndrome in 7 Patients with Ischemic Colitis Literature Review N. Yaramov, Sv. Toshev, K. Angelov, M. Sokolov, P. Gribnev, B. Pelrov, Ts. Lukanova |
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Abstract |
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Osteoporosis |
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CONTRIBUTIONS ORIGINALES Article |
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Syndrome d'Ogilvie chez la personne agee Etude retrospective de 40 cas Adeline Fraisse,Sophie Brosse, Patrick Manckoundia, Laura Popitean, Pierre Pfitzenmeyer |
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PREVENTION Group medical clinics to manage diabetes and hypertension |
| European Journal of Internal Medicine |
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Original article Hematocrit, urea and gender: The Hematocrit, Urea and Gender formula for prognosing progressive renal failure in diabetic nephropathy Nicolás Roberto Robles, Flavio Ferreira, Rocio Martinez-Gallardo, Joaquin Alvarez Gregori, Emilio Sanchez-Casado, Juan Jose Cubero b, Juan Macias |
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Abstract Objective: Diabetic nephropathy is a common cause of end stage renal disease. Notwithstanding, wide interindividual variations in the speed of progression of diabetic nephropathy are frequent. We have used the score of the HUGE formula to predict progression of kidney disease in a group of diabetic nephropathy patients. Design and methods: The sample consisted of 84 type 2 diabetic patients. At treatment entry, the mean age was 62.1±12.5 years and 59.5% were male. Blood pressure was measured at office at each visit. Serum creatinine, urea, hematocrit and 24 h proteinuria were analyzed every 6 months. HUGE score was calculated from gender, urea and hematocrit. Results: Mean HUGE score was 0.99±3.88. Using as cut off point 1.5, those patients who had a score equal or higher (n=31) showed a bigger increase in serum creatinine after one year (41.8±62.1%) than those subjects with scoreb1.5 (n=53) (18.7±38.6%, p=0.041). 5 patients with low HUGE score reached end stage renal failure (9.4%) and 10 patients in the high HUGE score group (32.3, p=0.008). When logistic regression analysis was performed only a HUGE score higher than 1.5 (p=0.003) and proteinuria higher than 2 g/day (p=0.041) were independently associated to CRF progression (creatinine increment>25%). Conclusions: In diabetic nephropathy patients the HUGE equation may be useful to detect the subjects prone to progressive renal failure. Wider samples will be needed to confirm this finding and, most important, its applicability to other kinds of nephropathy. |
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Vol 11, Special 10th Anniversary Edition Ten years of integrated care for the older in France Dominique Somme, MD, PhD, Paris Public Hospital Service, Georges Pompidou European Hospital, Department of Geriatrics, 20-40 rue Leblanc, 75015 Paris, France; Health Environment and Aging, National Institute of Health and Medical Research, EA 2506, Université de Versailles Saint-Quentin, Paris, France Matthieu de Stampa, MD, PhD, Paris Public Hospital Service, Sainte Périne Hospital, Department of Geriatrics, 11 rue Chardon Lagache, 75781 Paris Cedex 16, France; Health Environment and Aging, National Institute of Health and Medical Research, EA 2506, Université de Versailles Saint-Quentin, Paris, France |
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Abstract Background: This paper analyzes progress made toward the integration of the French health care system for the older and chronically ill population. Policies: Over the last 10 years, the French health care system has been principally influenced by two competing linkage models that failed to integrate social and health care services: local information and coordination centers, governed by the social field, and the gerontological health networks governed by the health field. In response to this fragmentation, Homes for the Integration and Autonomy for Alzheimer patients (MAIAs) is currently being implemented at experimental sites in the French national Alzheimer plan, using an evidence-based model of integrated care. In addition, the state’s reforms recently created regional health agencies (ARSs) by merging seven strategic institutions to manage the overall delivery of care. Conclusion: The French health care system is moving from a linkage-based model to a more integrated care system. We draw some early lessons from these changes, including the importance of national leadership and governance and a change management strategy that uses both top-down and bottom-up approaches to implement these reforms. |
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Preeclampsia and Hypertensive Disease in Pregnancy: Their Contributions
to Cardiovascular Risk Carolina Valdiviezo, MD; Vesna D. Garovic, MD; Pamela Ouyang, MBBS Department of Medicine (Valdiviezo, Ouyang), Division of Cardiology, Johns Hopkins University, Baltimore, Maryland; Division of Nephrology and Hypertension (Garovic), Mayo Clinic, Rochester, Minnesota |
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Abstract More women than men die each year of cardiovascular disease, which remains the leading cause of death in the United States. Sex-specific factors, including pregnancy-related disorders, should be considered when assessing cardiovascular (CV) risk in women. Hypertensive disorders of pregnancy have been associated with CV risk later in life and may identify women in whom earlier primary prevention may reduce their risk. This article reviews the physiologic changes in blood pressure during pregnancy, current definitions of hypertensive diseases of pregnancy and preeclampsia, and postulated pathophysiologic mechanisms leading to preeclampsia that might contribute to later CV risk. Also summarized are studies providing evidence on the association between hypertensive diseases of pregnancy and future CV risk. |
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Homocysteine after a methionine load in healthy subjects with adequate
B-vitamin status Mardia López-Alarcón, Adolfo Chávez-Negrete, Irene Montalvo-Velarde, Jorge Maldonado-Hernández, and Víctor Saúl Vital-Reyes |
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Abstract Background: Plasma homocysteine (Hcy) determination at 6-8 h after an oral methionine load (OML) allows for identification of some, but not all, individuals at risk to develop cardiovascular disease. It is probable that in some cases the Hcy increases occur later, or it elevates between normal ranges but in a sustained manner. However, the entire Hcy response curve has not been described. We undertook this study to determine Hcy concentrations from baseline to 24- and 48-h after an OML in non-B-vitamin deficient adult subjects with other risk factors for high levels of Hcy such as smoking and overweight. Methods: In a cross-over, clinical design, Hcy concentrations were determined at 2-h intervals throughout 12 h and at 24 h and 48 h after an OML (0.1 g/kg). Hcy and vitamin B6 (VB6) concentrations were measured by high-performance liquid chromatography (HPLC). Folic acid (FA) and vitamin B12 (VB12) were measured by radioimmunoassay (RIA). Statistical analysis included delta values and areas under the curve. Student t-test and repeated measurement analyses were conducted to control for confounders. Results: Twenty nine subjects with adequate Hcy, FA, VB6 and VB12 status were included. The maximum Hcy concentration occurred 8 h after the load and returned to baseline concentrations after 24 h. All subjects presented Hcy after the load within normal ranges, but smoking and overweight synergistically influenced the response to the challenge, producing a sustained elevation after the dose. Conclusions: Hcy concentrations after an OML remained above baseline for at least 24 h. Smoking and overweight affected the response to the methionine challenge. Key words: homocysteine response, oral methionine test, folic acid, vitamin B6, vitamin B12 |
| Dental Research Journal |
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Original Article Comparison of cardiovascular disease risk in two main forms of periodontitis Rahul Chopra, Sudhir R. Patil, Shivani Mathur |
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Abstract: Background: C-reactive protein (CRP) is an acute phase reactant and has been proved to be a significant predictor of future cardiovascular events. Recent studies have demonstrated a correlation between periodontitis and elevated CRP levels. However, comparison between the levels of CRP in two main forms of periodontitis is ambiguous. This study aims at determining and comparing the relative levels of serum CRP in aggressive and chronic periodontitis patients. Materials and Methods: A total of 240 systemically healthy subjects were divided into three groups of 80 based on having generalized aggressive periodontitis, chronic generalized periodontitis and non-periodontitis (NP; controls). Venous blood samples were collected for quantitative CRP analysis using turbidimetric immunoassay. Results: Mean CRP levels were significantly greater in both generalized aggressive periodontitis (7.49±2.31 mg/l) and chronic generalized periodontitis (4.88±1.80 mg/l) groups as compared to NP (0.68±0.23 mg/l) controls. Moreover, CRP levels were significantly higher in aggressive periodontitis as compared to chronic periodontitis patients. Also, CRP levels positively correlated with the amount of periodontal destruction as measured by probing depth and clinical attachment loss for both chronic generalized periodontitis and generalized aggressive periodontitis. Conclusion: Findings of the present study indicated that periodontitis should be of particular concern in younger individuals, where elevated levels of CRP may contribute to early or more rapid cardiovascular disease in susceptible patients. Thus, further research should be carried out at a community level to ascertain these findings. |
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Factors Contributing to
All-cause 30-day Readmissions A Structured Case Series Across 18 Hospitals Paul Feigenbaun\ MD, Estee Neuwirth PhD, Linda Trowbridge, MBA, Serge Teplitsky, RN, Carol Ann Barnes, MS, Emily Firemam BA, Jann Dorman, MBA, and Jim Bellows, PhD |
| Reviews - PREVENTION |
|
Myocardial
Ischemia in Women: Lessons From the NHLBI WISE Study Martha Gutati, MD, MS, FACC, FAHA; Leslee). Shaw, PhD, FACC, FAHA, FASNC; C. Noel Bairey Mers, MD, FACC, FAHA |
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Objective: To understand factors leading to all-cause 3D-day readmissions in a community hospital population. Research Design: Structured case series of 537 readmissions using chart reviews, interviews with treating physicians, patients and family caregivers, and overall case assessment by a nurse-physician team. Setting: Eighteen Kaiser Pennanente Northern California hospitals. Results: Forty-seven percent (250) of readmissions were assessed as potentially preventable; 11% (55) were assessed as very or completely preventable; and 36% (195) as slightly or moderately preventable. On average, 8.7 factors contributed to each potentially preventable readmission. Factors were related to care during the index stay (in 143 cases, 57% of potentially preventable read~ missions). the discharge process (168. 67%), and follow-up care (197, 79%). Missed opportunities to prevent readmissions were also related to quality improvement focus areas: transitions care planning and care coordination. clinical care, logistics of follow-up care, advance care planning and end-of-life care, and medication management. Conclusions: Multiple factors contributed to potentially prevent~ able readmissions in an integrated health care system with low baseline readmission rates. Reducing all-cause 3D-day readmissions may require a comprehensive approach addressing these areas. Future quality improvement efforts and research should identify existing and new tactics that can best prevent readmissions by addressing missed opportunities we identified. |
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ACO
final rule cuts provider burden Hospital Case Management. (Dec. 1,2011): |
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Design,
Implementation, and Evaluation of Population-Specific Telehealth Nursing
Services Mary H. Vinson Rex McCallum Deirdre K. Thornlow MOlY T. Champagne |
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Association between periodontal disease and stroke George S. Sfyroeras, MD, PhD,a Nikolaos Roussas, MD,b Vassileios G. Saleptsis, MD,b Christos Argyriou, MD,b and Athanasios D. Giannoukas, MSc, MD, PhD, FEBVS,b Athens and Larissa, Greece |
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Objective: Periodontitis is a very common human infection. There is evidence that periodontitis is associated with cerebrovascular disease (CVD) and stroke. The aim of this study is to examine the relationship between periodontal disease and CVD in observational studies. Method: An electronic search of the English literature using PubMed was conducted. A meta-analysis of the studies reporting on the risk of stroke in patients with periodontitis was performed. Results: Six prospective and seven retrospective studies met the inclusion criteria. Patients with both hemorrhagic and ischemic cerebrovascular events, fatal and nonfatal, were included. Definition of periodontitis was taken directly from included studies. Most studies have been adjusted for common cardiovascular risk factors. Separate statistical analysis was performed for prospective and retrospective studies. Overall adjusted risk of stroke in subjects with periodontitis was 1.47 times higher than in subjects without (95% confidence interval, 1.13-1.92;P .0035) in prospective and 2.63 times (95% confidence interval, 1.59-4.33;P .0002) in retrospective studies. The application of the trim and fill algorithm does not change the initial significant inference. Conclusions: There is evidence that periodontitis is associated with increased risk of stroke. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity of the studies as well as the differences in periodontitis definition. |
|
Noninvasive Diagnostic
Techniques for Coronary Disease in Women Eleni Vavas, MD; Susie N. Hong, MD; Stacey E. Rosen, MD; Jennifer H. Mieres, MD Department of Cardiology, Hofstra North 5hore·lIJ School of Medicine (Vavas, Rosen, Mieres), Manhasset, New York; Division of Cardiology, Beth Israel Deaconess Medical Center (Hong), Boston, Massachusetts |
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Abstract: Significant advances in medical treatment, medical technology, and the focus on sex-specific research have contributed to a reduction in cardiovascular mortality in women. Despite these advances, coronary artery disease (CAD) is the leading cause of cardiovascular death of women in the Western world. In the past 2 decades, the focused research on women at risk for CAD has helped to clarify our underslanding of some of the sex-specific factors that are important in the detection of CAD. In women, the detection and evaluation of physiologically significant CAD can be challenging. Many of the traditional tests that are designed to detect focal areas of coronary artery stenosis are less sensitive and specific in female patients, who have a greater burden of symptoms, higher atherosclerotic burden, and lower prevalence of obstructive coronary disease. In this article, we review the available evidence on the role of contemporary noninvasive diagnostic techniques in the evaluation of women with symptoms of CAD. |
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The
multiple facets of periostin in bone metabolism B. Merle· P. Garnero |
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Abstract Peliostin is a matricellular glutamate-containing protein expressed dwing ontogenesis and in adult connective tissues submitted to mechanical strains including bone and, more specifically, the periosteum, periodontal ligaments, tendons, heart valves, or skin. It is also expressed in neoplastic tissues, cardiovascular and fibrotic diseases, and during wound repair. Its biological functions are extensively investigated in fields such as cardiovascular physiology or oncology. Despite its initial identification in bone, investigations of periostin functions in bone-related physiopathology are less abundant. Recently, several studies have analyzed the potential role of periostin in bone biology and suggest that periostin may be an important regulator ofbone fOffilation. The aim of this article is to provide all extensive review on the implications of periostin in bone biology and its potential use in benign and metabolic bone diseases. |
|
Prevalence of
Potentially Preventable Unplanned Hospitalizations Caused by Therapeutic
Failures and Adverse Drug Withdrawal Events Among Older Veterans
Zachary A. Marcum,1,2,3 Mary Jo V. Pugh,4,S,6 Megan E. Amuan,7 Shenie L. Aspinall,J,8,9 Steven M. Handler,I,2,lO Cluistine M. Ruby,I,S and Joseph T. Hanlonl,2,J,8 |
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Efficacy and Tolerability of Aripiprazole: A 26-Week Switching Study
from Oral Antipsychotics Jung-Sun Lee1, Seockhoon Chung1, Joon-Noh Lee2, Jun Soo Kwon3, Do Hoon Kim4, Chul Eung Kim5, Kang Seob Oh6, Yang-Whan Jeon7, Min-Soo Lee8, Myung Ho Lim9, Hye-Ryein Chang10 and Chang Yoon Kim1 |
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THE CEYLON MEDICAL JOURNAL Established 1887 The Official Publication of the Sri Lanka Medical Association Volume 51, No.2, December 2006 Quarterly ISSN 0009-0875 |
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Coconut fats Abstract: In many areas of Sri Lanka the coconut tree and its products have for C€ln~ turies been an Integral part of life, and it has come to be called the "Tree of life". However, in the last few decades, the relationship between coconut fats and health has been the subject of much debate and misinformation. Coconut fats account for 80% of the fat Intake among Sri Lankans. Around 92% of these fats are saturated fats. This has lead to the belief that coconut fats are 'bad for health', particularly in relation to ischaemic heart disease. Yet most of the saturated fats in coconut are medium chain fatty acids whose properties and metabolism are different to those of animal origin. Medium chain fatty acids do not undergo degradation and re-esterification processes and are directly used in the body to produce energy. They are not as 'bad for health' as saturated fats. There is the need to clarify issues relating to intake of coconut fats and health, more particularly for populations that still depend on coconut fats for much of their fat intake. This paper describes the metabolism of coconut fats and its potentiai benefits, and attempts to highlight its benefits to remove certain misconceptions regarding its use. |
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DOROTHY C. WERTZ Eugenics Is Alive and Well: A Survey of Genetic Professionals around the WorId |
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Severe
Hypermagnesemia as a Result of Excessive Cathartic Ingestion in a Child
Without Renal Failure Ebru Kutsal, MD,* CumhurAydemir, MD,* NUufer Eldes, MD,* Fatma Demirel, MD,* Recep Polat, MD,* Ozan Taspznar, MD,* and Eyup Kulah, MD |
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Abstract: A 14-year.old girl was referred to our hospital with lethargy and hypotension and was found to have a serum magnesium level of 14.9 mg/dl after having received an magnesium hydroxide (Magnesia Calcinee) for 7 days because of constipation. She was lethargic, her blood pressure was 70/40 mm Hg, and electrocardiogram revealed prolonged corrected QT interval and first·degree atrioventricular block. She has no renal dysfunction. Emergency hemodialysis after her condition ameliorated, her serum magnesium levels returned to nannal. The present case suggests that massive oral magnesiwn ingestion with severe constipation and ileus may result severe hypermagnesemia without renal dysfunction. Key 'Yards: hypermagnesemia, toxicity, magnesium hydroxide, dysrhythmias Hypennagnesemia is a rare condition which usually iatrogenic; occurring, for example, after intravenous magnesium (Mg) administration, oral ingestion of Mgcontaining antacids or cathartics, or procedure-related retroperitoneal or peritoneal leakage of Mg-containing preparations. Hypennagnesemia after oral administration commonly occurs in older age groups with the presence of renal failure. 1 However, rare cases have been reported symptomatic hypennagnesemia without renal failure. 1 ,2 Initial symptoms of hypennagnesemia, such as nausea, vomiting, and weakness, are nonspecific and can progress rapidly to respiratOly depression, hypotension, cardiac arrest, and death. 1 Here, we report a child who developed severe hypennagnesemia as a result of ingestion of a excessive oral Mg-containing cathartics. |
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Evaluation
of a technique for blind placement of post-PYloric feeding tubes in
intensive care: application in patients with gastric ileus Andrew J. Lee Richard Eve Mark J. Bennett |
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Abstract Objective To evaluate a blind 'active' technique for the bedside placement of post-pyloric enteral feeding tubes in a critically ill population with proven gasttic ileus. Design and setting: An open study to evaluate the success rate and duration of the technique in cardiothoracic and general intensive care units of a tertiary referral hospital. Patients: 20 consecutive, ventilated patients requiring enteral nutrition, where feeding had failed via the gastric route. Interventions: Previously described insertion technique-the Corpak 10-10-10 protocol-for post-pyloric enteral feeding tube placement, modified after 20 min if placement had not been achieved, by insufflation of air inlo the stomach to promote pyloric opening. Measurements and results: A standard protocol and a set method to identify final tube position were used in each case. In 90% (18120) of cases tubes were placed on the first attempt, with an additional tube being successfully placed on the second attempt. The median time for tube placement was 18 min (range 3-55 min). In 20% (4120) insufflation of air was required to aid trans-pyloric passage. Conclusions: The previously described technique, modified by insufflation of air into the stomach in prolonged attempts to achieve trans-pylotic passage, proved to be an effective and cost efficient method to place post-pyloric enteral feeding tubes. This technique, even in the presence of gastric ileus, could be incorporated by all critical care facilities, without the need for any additional equipment or costs. This approach avoids the costs of additional equipment, time-delays and necessity to transfer the patient from the ICU for the more traditional techniques of endoscopy and radiographic screening. Keywords Enteral, nutrition . Critical care· Jejunum |
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PROLONGED
COLONIC PSEUDO-OBSTRUCTION (OGILVIE SYNDROME) IN AN OLDER WOMAN RESOLVED
WITH CONSERVATIVE TREATMENT Journal of the American Geriatries Society - Volume 44, Issue 8 (August 1996) - Copyright© 1996 American Geriatrics Society |
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Biofeedback
defaecation training for anismus B. Lestitr, F. Penninckx and R. Kerremans Department of Abdominal Surgery, University Clinic Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium Accepted: 3 June 1991 |
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Abstract Anismus, paradoxical external sphincter function, spastic pelvic floor syndrome, rectoanal dysnergia, abdomino-Ievator incoordination for abdominopelvic asychronism, are all due to paradoxical contraction of the striated sphincter apparatus during voiding and is characterised by prolonged and excessive straining at stool. Biofeedback is the treatment of choice and has to be introduced at an early stage. We present the results of an ambUlatory approach based on the integration ofsimulated balloon defaecation with small (50 ml) as well as constant rectal sensation volume, defaecometry and anal manometry. The pathophysiology visualised by the patient's own anorectal pressure recordings on the screen of a personal computer is explained and corrected. Sixteen patients were treated and followed for at least 1 year. Manometric data were normal except for an increased minimum residual pressure and rectal compliance. Nine patients could not evacuate a 50 ml bolus initially. Simulated defaecation became possible in seven out of these nine patients when the bolus was increased up to thc individual constant rectal sensation volume. 1\vo patients could not evacuate this volume either, while defaecation was made much less laborious in the other seven patients. Paradoxical contraction was immediately corrected in 7/16 cases. Also, as an immediate, objective benefit of a single training session, improved defaecation of a 50 ml bolus was observed in 11 patients. This effect was preserved after 6 weeks in nine cases; symptomatic recurrence did not occur in these patients during followup. This method ofdefaecation training has many advantages as compared with sphincter training using EMG electrodes eventually performed in the absence of a desire to defaecate or in lying position. It does not work, however, in all patients, especially in those with a "blind" rectum. Defaecometry is a valuable tool for the objective assessment of therapeutic effectiveness in patients with anismus. |
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The
efficacy of treatment of patients with severe constipation or recurrent
pseudo-obstruction with pyridostigmine C. J. O'Dea, S. J. H. Brookes and D. A. Wattchow Departments of Surgay ilrId of Human Phys!ology, Ainder'S Medical Centre and Alnders Univer"Sity, Bedford Pari<, South Australia |
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Abstract Objective Disorders of colomc motility. such as severe constipation and pseudo-obstmction, remain difficult to treat. The pathophysiology of these conditions is not compie tel}' understood, but previous studies suggest a deficienC)' of cholinergic innervation and an imb.lla.nce in autonomic regulation of colonic motor function as contributing factors. Therefore, increasing the availability of acetylcholine in the bowd wall with a cholinesterase inhibitor, such as pyridostigmine) may improve symptoms. Method We studied thirteen patients with severe constipation (slow transit type) or recurrent pseudo·obstmc· tion. The six patients with slow transit constipation had mechanical obstruction and peh~c floor dysfunction excluded, and normal calibre colon and slow transit confirmed, These patients were offercd pyridostigmine in an attempt to avoid surgery. The seven patients with pseudo-obstmction had dilated bowel on imaging, and mechanical obstmction was excluded. These patients received p}'ridostigmine whcn symptoms recurred, despite pre\~ous treatments. Pyridostigmine was initiated at 10 mg b.i.d. and increased if required. Results One of the SLX patients \\~th slow transit constipation reported impro\'ement of s}'mpmms and had concurrentl}' weaned anti-ps}'chotic medications. P}'ridostigmine was ceased in the remaining five patients due to lack of efficacy and/or side effects. Four patients proceeded to surgery for rcfractory symptoms. All seven paticnts \\~th pseudo-obstruction had some improvcment ofsymptollls with few side eftccts. Ofthese, two later had surgery for recurrent symptoms. Conclusion In patients \\~th slow transit constipation) treatment with pyridostigminc does not improve symptoms. However, it does improve symptoms in patients \\~th recurrent pseudo-obstruction \\~th few side effects, offering an extra treatment option for these patients. |
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Review Clinical review: Major consequences of illicit drug consumption Robert J Devlin1 and John A Henry2 1Guy’s and St Thomas’ NHS Foundation Trust, Lambeth Palace Road, London SE1 7EH, UK 2Department of Emergency Medicine, St Mary’s Hospital, South Wharf Road, London W2 1NY, UK |
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Widespread
suppression of huntingtin with convection-enhanced delivery of Sirna David K. Stiles a, Zhiming Zhang b, Pei Ge c, Brian Nelson a, Richard Grondin b, Yi Ai b, Peter Hardy b, Peter T. Nelson d, Andrei P. Guzaev e, Mark T. Butt f, Klaus Charisse c, Verbena Kosovrasti c, Lubomir Tchangov c, Michael Meys c, Martin Maier c, Lubomir Nechev c, Muthiah Manoharan c, William F. Kaemmerer a, Douglas Gwost a, Gregory R. Stewart a, Don M. Gash b, Dinah W.Y. Sah c |
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Short-Term
teriparatide therapy as an adjuntcive modality for
bisphosphonate-related osteonecrosis of the jaws Y.D, Kwon, D.W. Lee, b.K. Choi, J.W. Lee, D.Y. Kim |
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Abstract Summmy To review the effect of tetiparatide as an adjunctive modality for bisphosphonate·related osteonecrosis of the jaws (BRONJ), we describe a series of cases ofteliparatide therapy for the treatment of BRONJ and selial changes of serum osteoclacin (s-OC) and serum C-terminal telopep· tide cross-link of type I collagen (s-CTX). Introduction Management of BRONJ is quite challenging and the currently recommended modalities for BRONJ are still suboptimaL For the improvement of bony remodeling, some clinicians advocated bisphosphonate holiday although validity of this drug holiday has been debated so far. Re· cently, the use of teriparatide was introduced in several cases, but the number of the publication is limited and mostly anecdotal so far. Method Bisphosphonate was suspended and teriparatide was given to six patients diagnosed with BRONJ by single bone specialist. Medical record review and interviews were canied out. S-ClX and s-OC were measured at the baseline, 2 months and 3 months later teliparatide therapy. The outcome of the treatment and the change of biochemical markers were compared. Result In all six patients, s-OC values were significantly elevated within 2 months after teriparatide treatment and the BRONJ lesions were healed. S-CTX values were also elevated in four patients, whereas those of the rest two patients stayed within minimal change. The change was marginally significant at 3 months. Conclusion In terms of the multifactorial etiology of BRONJ, bone formation suppression was noticed in the patients. Based upon this finding, the short-term use of teriparatide might be beueficial to the resolution of BRONJ lesions by improving suppressed bone remodeling. |
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Perioperative
management of a parturient with hyponatraemia due to carbamazepine
therapy C. Staikou, A. Mani, G. Petropoulos |
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Hum
Gene Ther San Sebastian W., Richardson RM. Kells AP, Lamarre C, Bringas J, Piviroto P, Aguilar Salegio EA, Dea. |
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Genome-Wide
Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases
and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma Barbara S. Paugh, Alberto Broniscer, Chunxu Qu, Claudia P. Miller, Junyuan Zhang, Ruth G. Tatevossian, James M. Olson, J. Russell Geyer, Susan N. Chi, Nasjla Saba da Silva, Arzu Onar-Thomas, Justin N. Baker, Amar Gajjar, David W. Ellison, and Suzanne J. Baker |
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Critical
Oncogenic Mutations in Newly Diagnosed Pediatric Diffuse Intrinsic
Pontine Glioma Jacques Grill, MD, PhD, Stephanie Puget, MD PhD, Felipe Andreiuolo, MD, Cathy Philippe, Laura MacConaill, PhD, and Mark W. Kieran, MD, PhD. |
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A
phase I trial of carboplatin administered by convection-enhanced
delivery to patients with recurrent/progressive glioblastoma multiforme. Edward White a,b, Alison Bienemann b, Hannah Taylor b, Kirsten Hopkins c, Alison Cameron c, Steven Gill a,b |
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A
phase 2 study of pegylated interferon 945-2b (PEG-Intron) children with
diffuse intrinsic pontine glioma. Warren K, Bent R, Wolters PL, Prager A, Hanson R, Packer R, Shih J, Camphausen K. |
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Smooth
muscle dysfunction occurs independently of impaired
endothelium-dependent dilation in adults at risk of atherosclerosis Mark R. Adams, Jacqui Robinson, Robyn McCredie, J. Paul Seale, Keld E. Sorensen, John E. Deanfield, and David S. Celermajer J. Am. Coll. Cardiol. 1998;32;123-127 This information is current as of December 16, 2011 |
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Non-invasive
measurement of human endothelium dependent arterial responses: accuracy
and reproducibility Keld E Sorensen, David S Celermajer, David J Spiegelhalter, Dimitri Georgakopoulos, Jacqui Robinson, Odette Thomas, John E Deanfield |
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Abstract Objective To assess a non-invasive test for endothelial dysfunction, an important early event in the atherogenic process. Methods-Using high resolution ultrasound, the accuracy of detecting small changes in vessel diameter was assessed using phantom "arteries", and the same equipment was then used to measure flow mediated dilatation in the brachial artery of 40 healthy adults aged 22-51 years, studied on four occasions; intervals between scans were 1-2 days, 1-2 weeks, and 2-4 months. Results-Differences between pairs of phantom "arteries" with diameters 0-1-0'2 mm apart were correctly estimated in 162 of 264 cases (61%); no measurement by any of four independent observers was > 041 mm in error, and the mean error was 0*04 mm. For in vivo scans, the overall coefficient of variation for flow mediated dilatation was 1-8% (1.6% for women, 1-9% for men, P = 0.18). In 34/40 subjects (85%), all values for flow mediated dilatation were within 2-5% of the overall mean for each subject. A nested analysis of variance showed the expected between patient variability, and also significant day to day variation, but little between weeks or months. Using these data to generate power function analyses, we calculated that for individuals, an improvement in flow mediated dilatation of 4-8% is significantly greater than natural variability. In clinical trials, a mean improvement in flow mediated dilatation of at least 2% would usually be required to detect a treatment benefit, with much larger subject numbers needed for a parallel group compared to a crossover trial design. Conclusions-Vascular responses to endothelium dependent and independent stimuli in systemic arteries can be studied non-invasively in man. Subjects should be studied on at least two occasions before and after any intervention, to optimise the chance of showing a significant effect from any potentially beneficial therapy. |
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Impairment
of Endothelium-dependent Dilation Is an Early Event in Children with
Familial Hypercholesterolemia and Is Related to the Lipoprotein (a)
Level Keld E. Sorensen, David S. Celermajer, Dimitri Georgakopoulos, Geoffrey Hatcher, D. John Betteridge, and John E. Deanfield |
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Endothelium-Dependent
Dilation in the Systemic Arteries of Asymptomatic Subjects Relates to
Coronary Risk Factors and Their Interaction DAVID S. CELERMAJER, PHD, FRACP, KELD E. SORENSEN, MD, CATHERINE BULL, MD, BCHIR, FRCP, JACQUI ROBINSON, RN, JOHN E. DEANFIELD, MB, BCwn, FRCP |
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Differences
in the Effect of Cigarette Smoking on Endothelial Function in Chinese
and White Adults Kam S. Woo, MB, BS, MD, FRACP; Jacqui T.C. Robinson, RN; Ping Chook, MPhil, MD; Mark R. Adams, MBBS, FRACP; Gabriel Yip, MB, ChB, MRCP; Z.J. Mai, MD; Chris W.K. Lam, PhD; Keld E. Sorensen, MD; John E. Deanfield, MB, ChB, FRCP; and David S. Celermajer, MB, BS, PhD, FRACP |
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Cigarette
smoking is associated with dose-related and potentially reversible
impairment of endothelium-dependent dilation in healthy young adults DS Celermajer, KE Sorensen, D Georgakopoulos, C Bull, O Thomas, J Robinson and JE Deanfield |
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Arterial
reactivity is significantly impaired in normotensive young adults after
successful repair of aortic coarctation in childhood HM Gardiner, DS Celermajer, KE Sorensen, D Georgakopoulos, J Robinson, O Thomas and JE Deanfield 1994 |
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Aging
Is Associated With Endothelial Dysfunction in Healthy Years Before the
Age-Related Decline in Women David S. Celermajer, PhD, FRACP, Keld E. Sorensen, MD. David J. Spiegelhalter, PhD, Dimitri Georgakopoulos, MD. Jacqui Robinson, RN, John E. Deanfield, MB. BChir, FRCP |
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Vitamin
E and Prostate Cancer: Research Focus Turns to Biologic Mechanisms By Caroline McNell |
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The
national health system: future possibilities for the clinical laboratory Nicola Pansini |
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Abstract Background: The heavy burden of the costs of medical care has brought changes in the public health policy. The changes are partly related to the health management factors, but several cultural, social and environmental factors have also had a significant impact on healthcare. The role of the laboratory is now considered amidst changes that have occurred in the American health model (free-trader) and in the European–Canadian model (universalistic). Moreover, costs and clinical decision-making in laboratories in Italy have also changed in response to the new focus on the pre- and post-analytical phases of the testing process. Methods: In the present study, we used the Laboratory Information System (LIS) to evaluate whether the time involved in stages in the turnaround time (TAT) (admission, performance of tests, validation and decision-making for treatment) were reduced following improvements made to the laboratory organization and management of the pre-analytical and post-analytical phases. In particular, an analysis was made of laboratory testing for myocardial markers in patients with acute coronary syndrome. Results: TAT for myocardial markers in an emergency setting was reduced by 30% following changes made in the laboratory organization and in the management of the pre-analytical and post-analytical phases of the testing process. Conclusions: Thanks to changes in healthcare service/system in Italy, laboratory services will now play a crucial role in cultural and socioeconomic changes, particularly where testing processes and techniques are concerned. D 2002 Elsevier Science B.V. All rights reserved. |
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Research Article |
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Contemporary
Management of the Painful Bladder: A Systematic Review |
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Abstract |
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Steroid
5a-Reductase as a Novel Therapeutic Target for Schizophrenia and Other
Neuropsychiatric Disorder |
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Urine
culture doubtful in determining etiology of diffuse symptoms among
elderly individuals: a cross-sectional study of 32 nursing homes
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Abstract Background: |
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Unnecessary
use of fluoroquinolone antibiotics in hospitalized patients |
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Abstract Background: |
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Clinical
trial: lubiprostone in patients with constipationassociated irritable
bowel syndrome – results of two randomized, placebo-controlled studies
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Abnormal urinalysis finding triggered antibiotic prescription for asymptomatic bacteriuria in the ED |
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Finasteride
Treatment of Hair Loss in Women |
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Predicting
outcome of children with diffuse intrinsic pontine gliomas using
multiparametric imaging |
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Potential
Role for Valproate in the Treatment of High-Risk Brain Tumors of
Childhood - Results from a Retrospective Observational Cohort Sudy |
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Choice
of Antihypertensive Treatment in Subjects with Pre-Diabetes, Is There a
Dream After the Navigator |
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The
efficacy and safety study of dietary supplement PURIAM110 on non-insulin
taking Korean adults in the stage of pre-diabetes and diabetes mellitus:
protocol for a randomized, double-blind, placebo-controlled, and
multicenter trial-pilot study |
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Abstract |
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Screening
for Diabetes and Pre-Diabetes With Proposed A1C-Based Diagnostic
Criteria |
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Screening
Adults for Pre-Diabetes and Diabetes May Be Cost-Saving |
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Psychology and Health. |
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Prevalence,
Diagnosis, and Treatment of Impaired Fasting Glucose and Impaired
Glucose Tolerance in Nondiabetic U.S. Adults |
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Pre-Diabetes
and the Risk for Cardiovascular Disease
A Systematic Review of the Evidence |
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Genomic
Aberrations in pediatric diffuse intrinsic pontine gliomas |
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MYOCARDIAL
INFARCTION IN NONDIABETIC AND PREDIABETIC POPULATION : A RETROSPECTIVE
ANALYSIS |
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Abstract |
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Diet,
Physical Activity, and Cardiovascular Disease Risk Factors Among Older
Chinese Americans Living in New York City. |
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DIABRISK
- SL Prevention of cardio-metabolic disease with life style modification
in young urban Sri Lankan’s
- study protocol for a |
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Abstract |
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A
cardiovascular disease risk factor screening program designed to reach
rural residents of Maine, USA |
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A B S T R A C T |
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The
clinical challenge of SIADH—three cases |
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The
pre-diabetes Risk Education and Physical Activity Recommendation and
Encouragement (PREPARE) programme study: are improvements in glucose
regulation sustained at 2 years? |
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Regression
to normoglycaemia by fenofibrate in pre-diabetic subjects complicated
with hypertriglyceridaemia: a prospective randomized controlled trial. |
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Exercise
prescription for patients with type 2diabetes and pre-diabetes: A
position statement from exercise and sports cience Australia
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Sexual side-effects of
contemporary antidepressants: review |
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Short Repor: Epidemilogy |
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Downin oireyhtymaan liittyvien laake-tieteellisten ongelmien hyva hoito |
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Thermographic visualization of
changes in periphe |
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Australians with Down syndrome |
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Thermoregulation and
Thermography in Neonatal Physiology and Disease |
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Abstract |
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Comparison
of 3 Infrared Thermal Detection Systems and Self-Report for Mass Fever
Screening |
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Health
conditions associated with aging and end of life of adults with Down
syndrome |
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Abstract |
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Infrared imaging technology and biological applications |
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Senile myoclonic epilepsy: Delineation of a common condition associated
with Alzheimer’s disease in Down syndrome |
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Survival in Elderly Persons
with Down Syndrome |
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Ten-year survival among HIV-1
infected subjects with AIDS or non -AIDS- defining malignancies |
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Persons with Down syndrome in residential care in Israel: Trends for
1998-2006 |
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Minocycline Suppresses
Activation of Nuclear Factor of Activated T Cells 1 (NFAT1) in Human CD4
+ T Cells |
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Genomic aberrations in pediatric
diffuse intrinsic pontine gliomas |
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Angioedema-type swelling and
herpes simplex virus reactivation following hyaluronic acid injection
for lip augmentation |
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Non-invasive detection of endothelial dysfunction in children and adults
at risk of atherosclerosis |
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Angiotensin-converting enzyme genotype is
not associated with endothelial dysfunction in subjects without other
coronary risk factors |
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Abstract |
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Impaired
Vascular Reactivity in Insulin-Dependent Diabetes Mellitus is
Related to Disease Duration and Low Density Lipoprotein Cholesterol
Levels |
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Atherosclerosis in the Human Brachial Artery
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